Brucella species are gram-negative, facultative intracellular bacteria that cause chronic brucellosis in humans and many domestic mammals. The genus Brucella contains six species based on the preferential host specificity: B. melitensis (goats), B. abortus (cattle), B. suis (swine), B. canis (dogs), B. ovis (sheep) and B. neotomae (desert wood rat). The first four species are pathogenic to humans making brucellosis a zoonotic disease. The first three species listed are the main threats to humans. Five Brucella genomes from the first three Brucella species have been sequenced published, which display an average of >94% identity at the nucleotide level and >98% at the protein level. Brucella infects the body via the skin, respiratory tract or digestive tract. Upon entry, the bacteria invade the blood and lymphatics where they multiply inside phagocytic cells and eventually cause bacteremia. There is no human Brucella vaccine available. Cell-mediated immunity (CMI) is required to protect against Brucella infection. However, the mechanism of host-Brucella interaction is still unclear and requires intensive investigation. More general information about Brucella spp is available in Here. The Brucella Bioinforamtics Portal (BBP) contains detailed information about Brucella genomes.
GenoMesh has used Brucella spp. as an example of showing the novelty and power of genome-wide literature mining using the GenoMesh algorithm. Please access and explore individual GenoMesh programs and find out what GenoMesh can do.
References of Brucella Genomes: